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Biologic Solutions

The Zimmer Biomet Biologics product portfolio represents the passionate pursuit of the most innovative and clinically relevant solutions addressing the needs of surgeons and their patients. As a leader in autologous therapies, Zimmer Biomet Biologics offers a myriad of solutions for hard tissue applications, including bone grafting products, platelet and plasma concentration systems, a BBMA (blood and bone marrow aspirate) concentration system, an autologous activation system and bone marrow aspiration needles (ancillary products). Also offered are soft tissue management products.

The philosophy defining our hard tissue products is based on the complex process involved in tissue repair, wherein the matrix/scaffold (osteoconductive), signaling proteins (osteopromotive and osteoinductive), and tissue forming cells (osteogenic) work in concert to form new tissue (bone). This “Bone Remodeling Triad” is the cornerstone of the Zimmer Biomet Biologics product portfolio, which is one of the broadest portfolios in the market today. 

 

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The Subchondroplasty®(SCP®) Procedure

The Subchondroplasty® (SCP ®) Procedure is a fluoroscopic, minimally-invasive procedure that targets and fills subchondral bone defects with a hard-setting bone substitute material that is replaced with new bone during the healing process.

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Autologous Therapies

Autologous cellular therapies are at the forefront of regenerative medicine.  Such treatment options include blood and bone marrow aspirate and concentration.  Zimmer Biomet offers Platelet-Rich Plasma (PRP) products to produce PRP which can be mixed with autograft or allograft materials to impart better graft-handling characteristics.1

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Bone Grafting

Successful bone grafts address each part of the bone healing triad, wherein the matrix/scaffold (osteoconductive), signaling proteins (osteopromotive and osteoinductive), and tissue-forming cells (osteogenic) work in concert to form new tissue (bone).2

Although autograft is considered the gold standard for orthopedic procedures requiring graft material, it has known limitations with associated donor site morbidity and limited availability.3 Synthetic bone graft substitutes have been developed to overcome these limitations of donor site morbidity and limited availability. 

 

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References

  1. Lewandrowski et al, Advances in Spinal Fusion – Molecular Science, Biomechanics and Clinical Management, p. 375-389, Marcel Dekker, Inc., 2004.

  2. Hung NN. Basic Knowledge of Bone Grafting. In: Zorzi A, de Miranda JB, eds. Bone Grafting. Rijeka, Croatia: InTech; 2012:11-38.

  3. Khan et al, The Biology of Bone Grafting, J Am Acad Orthop Surg 2005:13:77–86.

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This material is intended for health care professionals.  Distribution to any other recipient is prohibited.
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